660.9K XNAS Volume
XNAS 24 Apr, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Kathryn Haviland | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 88.59 per share. | 01 Apr 2025 | 100 | 165,929 (0%) | 0% | 88.6 | 8,859 | Common Stock |
| Kathryn Haviland | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 87.34 per share. | 01 Apr 2025 | 1,200 | 166,029 (0%) | 0% | 87.3 | 104,808 | Common Stock |
| Kathryn Haviland | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 86.14 per share. | 01 Apr 2025 | 598 | 167,229 (0%) | 0% | 86.1 | 51,512 | Common Stock |
| Kathryn Haviland | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 85.47 per share. | 01 Apr 2025 | 600 | 167,827 (0%) | 0% | 85.5 | 51,282 | Common Stock |
| Christina Rossi | CHIEF OPERATING OFFICER | Sale of securities on an exchange or to another person at price $ 95.02 per share. | 24 Mar 2025 | 2,274 | 69,266 (0%) | 0% | 95.0 | 216,075 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Mar 2025 | 7,500 | 97,500 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 88.37 per share. | 12 Mar 2025 | 1,800 | 152,396 (0%) | 0% | 88.4 | 159,066 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 87.62 per share. | 12 Mar 2025 | 5,700 | 154,196 (0%) | 0% | 87.6 | 499,434 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share. | 12 Mar 2025 | 7,500 | 159,896 (0%) | 0% | 36.1 | 270,375 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 88.80 per share. | 05 Mar 2025 | 5,284 | 72,924 (0%) | 0% | 88.8 | 469,219 | Common Stock |
| Kathryn Haviland | CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 88.80 per share. | 05 Mar 2025 | 16,151 | 168,427 (0%) | 0% | 88.8 | 1,434,209 | Common Stock |
| Tracey L. McCain | EVP AND CHIEF LEGAL OFFICER | Sale of securities on an exchange or to another person at price $ 88.80 per share. | 05 Mar 2025 | 5,262 | 66,583 (0%) | 0% | 88.8 | 467,266 | Common Stock |
| Christina Rossi | CHIEF OPERATING OFFICER | Sale of securities on an exchange or to another person at price $ 88.80 per share. | 05 Mar 2025 | 6,495 | 71,540 (0%) | 0% | 88.8 | 576,756 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 88.80 per share. | 05 Mar 2025 | 1,326 | 16,944 (0%) | 0% | 88.8 | 117,749 | Common Stock |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Sale of securities on an exchange or to another person at price $ 88.80 per share. | 05 Mar 2025 | 5,157 | 49,606 (0%) | 0% | 88.8 | 457,942 | Common Stock |
| Fouad Namouni | PRESIDENT, R & D | Sale of securities on an exchange or to another person at price $ 88.80 per share. | 05 Mar 2025 | 6,489 | 75,781 (0%) | 0% | 88.8 | 576,223 | Common Stock |
| Becker Hewes | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 88.80 per share. | 05 Mar 2025 | 4,863 | 35,651 (0%) | 0% | 88.8 | 431,834 | Common Stock |
| Becker Hewes | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 87.42 per share. | 05 Mar 2025 | 2,691 | 32,960 (0%) | 0% | 87.4 | 235,247 | Common Stock |
| Becker Hewes | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 87.98 per share. | 05 Mar 2025 | 2,541 | 30,419 (0%) | 0% | 88.0 | 223,557 | Common Stock |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 88.80 per share. | 05 Mar 2025 | 3,733 | 41,996 (0%) | 0% | 88.8 | 331,490 | Common Stock |
| Percy H. Carter | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 88.80 per share. | 05 Mar 2025 | 3,530 | 56,865 (0%) | 0% | 88.8 | 313,464 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 88.80 per share. | 05 Mar 2025 | 5,766 | 146,630 (0%) | 0% | 88.8 | 512,021 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 11,000 | 78,208 (0%) | 0% | 0 | Common Stock | |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 22,000 | 22,000 | - | - | Stock Option (Right to Buy) | |
| Kathryn Haviland | CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 70,400 | 70,400 | - | - | Stock Option (Right to Buy) | |
| Kathryn Haviland | CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 35,200 | 184,578 (0%) | 0% | 0 | Common Stock | |
| Tracey L. McCain | EVP AND CHIEF LEGAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 22,000 | 22,000 | - | - | Stock Option (Right to Buy) | |
| Tracey L. McCain | EVP AND CHIEF LEGAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 11,000 | 71,845 (0%) | 0% | 0 | Common Stock | |
| Christina Rossi | CHIEF OPERATING OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 13,200 | 78,035 (0%) | 0% | 0 | Common Stock | |
| Christina Rossi | CHIEF OPERATING OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 26,400 | 26,400 | - | - | Stock Option (Right to Buy) | |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 89.63 per share. | 01 Mar 2025 | 775 | 20,698 (0%) | 0% | 89.6 | 69,463 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 6,506 | 21,473 (0%) | 0% | 0 | Common Stock | |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 7,007 | 7,007 | - | - | Stock Option (Right to Buy) | |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 90.92 per share. | 01 Mar 2025 | 238 | 20,460 (0%) | 0% | 90.9 | 21,639 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 93.42 per share. | 01 Mar 2025 | 484 | 19,345 (0%) | 0% | 93.4 | 45,215 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 95.16 per share. | 01 Mar 2025 | 1,075 | 18,270 (0%) | 0% | 95.2 | 102,297 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 92.00 per share. | 01 Mar 2025 | 631 | 19,829 (0%) | 0% | 92 | 58,052 | Common Stock |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 22,000 | 22,000 | - | - | Stock Option (Right to Buy) | |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 11,000 | 54,763 (0%) | 0% | 0 | Common Stock | |
| Fouad Namouni | PRESIDENT, R & D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 13,200 | 82,270 (0%) | 0% | 0 | Common Stock | |
| Fouad Namouni | PRESIDENT, R & D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 26,400 | 26,400 | - | - | Stock Option (Right to Buy) | |
| Becker Hewes | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 11,000 | 40,514 (0%) | 0% | 0 | Common Stock | |
| Becker Hewes | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 22,000 | 22,000 | - | - | Stock Options (Right to Buy) | |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 11,000 | 45,729 (0%) | 0% | 0 | Common Stock | |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 22,000 | 22,000 | - | - | Stock Option (Right to Buy) | |
| Percy H. Carter | CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 11,000 | 60,395 (0%) | 0% | 0 | Common Stock | |
| Percy H. Carter | CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 22,000 | 22,000 | - | - | Stock Option (Right to Buy) | |
| Christina Rossi | CHIEF OPERATING OFFICER | Sale of securities on an exchange or to another person at price $ 95.14 per share. | 20 Feb 2025 | 2,274 | 64,835 (0%) | 0% | 95.1 | 216,348 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jan 2025 | 10,000 | 105,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share. | 21 Jan 2025 | 10,000 | 167,557 (0%) | 0% | 36.1 | 360,500 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 110.61 per share. | 21 Jan 2025 | 200 | 152,396 (0%) | 0% | 110.6 | 22,122 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 109.92 per share. | 21 Jan 2025 | 7,400 | 152,596 (0%) | 0% | 109.9 | 813,408 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 109.11 per share. | 21 Jan 2025 | 7,561 | 159,996 (0%) | 0% | 109.1 | 824,981 | Common Stock |
| Kathryn Haviland | CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 110.24 per share. | 21 Jan 2025 | 1,446 | 149,378 (0%) | 0% | 110.2 | 159,407 | Common Stock |
| Christina Rossi | CHIEF OPERATING OFFICER | Sale of securities on an exchange or to another person at price $ 110.78 per share. | 21 Jan 2025 | 808 | 67,230 (0%) | 0% | 110.8 | 89,510 | Common Stock |
| Christina Rossi | CHIEF OPERATING OFFICER | Sale of securities on an exchange or to another person at price $ 108.99 per share. | 21 Jan 2025 | 529 | 68,854 (0%) | 0% | 109.0 | 57,656 | Common Stock |
| Christina Rossi | CHIEF OPERATING OFFICER | Sale of securities on an exchange or to another person at price $ 110.00 per share. | 21 Jan 2025 | 816 | 68,038 (0%) | 0% | 110 | 89,760 | Common Stock |
| Christina Rossi | CHIEF OPERATING OFFICER | Sale of securities on an exchange or to another person at price $ 111.81 per share. | 21 Jan 2025 | 121 | 67,109 (0%) | 0% | 111.8 | 13,529 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share. | 13 Jan 2025 | 5,000 | 162,557 (0%) | 0% | 36.1 | 180,250 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 102.28 per share. | 13 Jan 2025 | 5,000 | 157,557 (0%) | 0% | 102.3 | 511,400 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Jan 2025 | 5,000 | 115,000 | - | - | Stock Option (Right to Buy) | |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share. | 13 Jan 2025 | 2,250 | 17,217 (0%) | 0% | 36.1 | 81,113 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 100.00 per share. | 13 Jan 2025 | 2,250 | 14,967 (0%) | 0% | 100 | 225,000 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Jan 2025 | 2,250 | 2,250 | - | - | Stock Option (Right to Buy) | |
| W. Jeffrey Albers | Director | Sale of securities on an exchange or to another person at price $ 91.15 per share. | 19 Dec 2024 | 3,800 | 159,657 (0%) | 0% | 91.2 | 346,370 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 89.01 per share. | 19 Dec 2024 | 5,180 | 163,457 (0%) | 0% | 89.0 | 461,072 | Common Stock |
| Albers Jeffrey W. | Director | Sale of securities on an exchange or to another person at price $ 88.28 per share. | 19 Dec 2024 | 3,920 | 168,637 (0%) | 0% | 88.3 | 346,058 | Common Stock |
| Jeffrey Albers W. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Dec 2024 | 15,000 | 120,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey Albers W. | Director | Sale of securities on an exchange or to another person at price $ 91.96 per share. | 19 Dec 2024 | 2,100 | 157,557 (0%) | 0% | 92.0 | 193,116 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share. | 19 Dec 2024 | 15,000 | 172,557 (0%) | 0% | 36.1 | 540,750 | Common Stock |
| Rossi Christina | CHIEF OPERATING OFFICER | Sale of securities on an exchange or to another person at price $ 95.88 per share. | 18 Dec 2024 | 2,166 | 69,491 (0%) | 0% | 95.9 | 207,676 | Common Stock |
| Rossi Christina | CHIEF OPERATING OFFICER | Sale of securities on an exchange or to another person at price $ 96.50 per share. | 18 Dec 2024 | 108 | 69,383 (0%) | 0% | 96.5 | 10,422 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share. | 12 Dec 2024 | 1,600 | 16,786 (0%) | 0% | 15.0 | 24,016 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Dec 2024 | 1,600 | 0 | - | - | Stock Option (Right to Buy) | |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 93.99 per share. | 12 Dec 2024 | 619 | 14,967 (0%) | 0% | 94.0 | 58,180 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 92.88 per share. | 12 Dec 2024 | 1,200 | 15,586 (0%) | 0% | 92.9 | 111,456 | Common Stock |
| Kathryn Haviland | CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 97.76 per share. | 29 Nov 2024 | 207 | 150,824 (0%) | 0% | 97.8 | 20,236 | Common Stock |
| Kathryn Haviland | CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 96.74 per share. | 29 Nov 2024 | 1,746 | 151,031 (0%) | 0% | 96.7 | 168,908 | Common Stock |
| Kathryn Haviland | CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 95.40 per share. | 29 Nov 2024 | 400 | 152,777 (0%) | 0% | 95.4 | 38,160 | Common Stock |
| Christina Rossi | CHIEF OPERATING OFFICER | Sale of securities on an exchange or to another person at price $ 95.10 per share. | 27 Nov 2024 | 2,274 | 71,657 (0%) | 0% | 95.1 | 216,257 | Common Stock |
| Lonnel Coats | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 69.79 per share. | 20 Nov 2024 | 7,500 | 20,754 (0%) | 0% | 69.8 | 523,425 | Common Stock |
| Lonnel Coats | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Nov 2024 | 1,312 | 3,188 | - | - | Stock Option (Right to Buy) | |
| Lonnel Coats | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Nov 2024 | 7,500 | 0 | - | - | Stock Option (Right to Buy) | |
| Lonnel Coats | Director | Sale of securities on an exchange or to another person at price $ 94.87 per share. | 20 Nov 2024 | 9,824 | 2,242 (0%) | 0% | 94.9 | 932,003 | Common Stock |
| Lonnel Coats | Director | Sale of securities on an exchange or to another person at price $ 94.99 per share. | 20 Nov 2024 | 213 | 12,066 (0%) | 0% | 95.0 | 20,233 | Common Stock |
| Lonnel Coats | Director | Sale of securities on an exchange or to another person at price $ 94.24 per share. | 20 Nov 2024 | 5,287 | 12,279 (0%) | 0% | 94.2 | 498,247 | Common Stock |
| Lonnel Coats | Director | Sale of securities on an exchange or to another person at price $ 93.15 per share. | 20 Nov 2024 | 4,500 | 17,566 (0%) | 0% | 93.2 | 419,175 | Common Stock |
| Lonnel Coats | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 76.24 per share. | 20 Nov 2024 | 1,312 | 22,066 (0%) | 0% | 76.2 | 100,027 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 102.00 per share. | 07 Nov 2024 | 5,000 | 157,557 (0%) | 0% | 102 | 510,000 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Nov 2024 | 5,000 | 135,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share. | 07 Nov 2024 | 5,000 | 162,557 (0%) | 0% | 36.1 | 180,250 | Common Stock |
| Fouad Namouni | PRESIDENT, R & D | Sale of securities on an exchange or to another person at price $ 89.32 per share. | 03 Oct 2024 | 3,633 | 69,070 (0%) | 0% | 89.3 | 324,500 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Sep 2024 | 10,000 | 140,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 85.12 per share. | 09 Sep 2024 | 7,734 | 157,557 (0%) | 0% | 85.1 | 658,318 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 85.86 per share. | 09 Sep 2024 | 11,968 | 165,291 (0%) | 0% | 85.9 | 1,027,572 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share. | 09 Sep 2024 | 10,000 | 177,259 (0%) | 0% | 36.1 | 360,500 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 95.23 per share. | 15 Aug 2024 | 4,409 | 67,208 (0%) | 0% | 95.2 | 419,869 | Common Stock |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share. | 05 Aug 2024 | 157 | 34,886 (0%) | 0% | 36.1 | 5,660 | Common Stock |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Aug 2024 | 12,350 | 0 | - | - | Stock Option (Right to Buy) | |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Aug 2024 | 10,572 | 6,928 | - | - | Stock Option (Right to Buy) | |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Aug 2024 | 8,450 | 0 | - | - | Stock Option (Right to Buy) | |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Aug 2024 | 4,331 | 20,669 | - | - | Stock Option (Right to Buy) | |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Aug 2024 | 5,011 | 0 | - | - | Stock Option (Right to Buy) | |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Aug 2024 | 1,042 | 0 | - | - | Stock Option (Right to Buy) | |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Aug 2024 | 157 | 0 | - | - | Stock Option (Right to Buy) | |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 93.19 per share. | 05 Aug 2024 | 41,913 | 34,729 (0%) | 0% | 93.2 | 3,905,872 | Common Stock |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 86.60 per share. | 05 Aug 2024 | 12,350 | 76,642 (0%) | 0% | 86.6 | 1,069,510 | Common Stock |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 61.31 per share. | 05 Aug 2024 | 10,572 | 64,292 (0%) | 0% | 61.3 | 648,169 | Common Stock |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 54.13 per share. | 05 Aug 2024 | 8,450 | 53,720 (0%) | 0% | 54.1 | 457,399 | Common Stock |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 43.15 per share. | 05 Aug 2024 | 4,331 | 45,270 (0%) | 0% | 43.2 | 186,883 | Common Stock |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 81.44 per share. | 05 Aug 2024 | 5,011 | 40,939 (0%) | 0% | 81.4 | 408,096 | Common Stock |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 51.06 per share. | 05 Aug 2024 | 1,042 | 35,928 (0%) | 0% | 51.1 | 53,205 | Common Stock |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 54.13 per share. | 03 Jul 2024 | 3,850 | 47,613 (0%) | 0% | 54.1 | 208,401 | Common Stock |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Sale of securities on an exchange or to another person at price $ 111.29 per share. | 03 Jul 2024 | 8,817 | 43,763 (0%) | 0% | 111.3 | 981,244 | Common Stock |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 54.13 per share. | 03 Jul 2024 | 8,817 | 52,580 (0%) | 0% | 54.1 | 477,264 | Common Stock |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jul 2024 | 3,850 | 0 | - | - | Stock Option (Right to Buy) | |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jul 2024 | 8,817 | 3,850 | - | - | Stock Option (Right to Buy) | |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Sale of securities on an exchange or to another person at price $ 111.20 per share. | 03 Jul 2024 | 3,850 | 43,763 (0%) | 0% | 111.2 | 428,120 | Common Stock |
| Christina Rossi | CHIEF OPERATING OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 9,625 | 73,931 (0%) | 0% | 0 | Common Stock | |
| Percy H. Carter | CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 7,500 | 49,395 (0%) | 0% | 0 | Common Stock | |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Jun 2024 | 333 | 12,667 | - | - | Stock Option (Right to Buy) | |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Sale of securities on an exchange or to another person at price $ 111.15 per share. | 28 Jun 2024 | 333 | 43,763 (0%) | 0% | 111.2 | 37,013 | Common Stock |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 54.13 per share. | 28 Jun 2024 | 333 | 44,096 (0%) | 0% | 54.1 | 18,025 | Common Stock |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.00 per share. | 21 Jun 2024 | 13,741 | 71,056 (0%) | 0% | 18 | 247,338 | Common Stock |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jun 2024 | 15,500 | 13,000 | - | - | Stock Option (Right to Buy) | |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jun 2024 | 24,200 | 0 | - | - | Stock Option (Right to Buy) | |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jun 2024 | 7,041 | 0 | - | - | Stock Option (Right to Buy) | |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jun 2024 | 13,471 | 0 | - | - | Stock Option (Right to Buy) | |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Sale of securities on an exchange or to another person at price $ 102.44 per share. | 21 Jun 2024 | 300 | 43,763 (0%) | 0% | 102.4 | 30,732 | Common Stock |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Sale of securities on an exchange or to another person at price $ 103.05 per share. | 21 Jun 2024 | 13,062 | 44,063 (0%) | 0% | 103.0 | 1,346,039 | Common Stock |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Sale of securities on an exchange or to another person at price $ 104.14 per share. | 21 Jun 2024 | 40,353 | 57,125 (0%) | 0% | 104.1 | 4,202,361 | Common Stock |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Sale of securities on an exchange or to another person at price $ 104.98 per share. | 21 Jun 2024 | 18,752 | 97,478 (0%) | 0% | 105.0 | 1,968,585 | Common Stock |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Sale of securities on an exchange or to another person at price $ 105.82 per share. | 21 Jun 2024 | 1,567 | 116,230 (0%) | 0% | 105.8 | 165,820 | Common Stock |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 54.13 per share. | 21 Jun 2024 | 15,500 | 117,797 (0%) | 0% | 54.1 | 839,015 | Common Stock |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share. | 21 Jun 2024 | 24,200 | 102,297 (0%) | 0% | 36.1 | 872,410 | Common Stock |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.00 per share. | 21 Jun 2024 | 7,041 | 78,097 (0%) | 0% | 18 | 126,738 | Common Stock |
| Alexis A. Borisy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 4,570 | 4,570 | - | - | Stock Option (Right to Buy) | |
| Alexis A. Borisy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 2,242 | 74,160 (0%) | 0% | 0 | Common Stock | |
| Mark Alan Goldberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 4,570 | 4,570 | - | - | Stock Option (Right to Buy) | |
| Mark Alan Goldberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 2,242 | 18,254 (0%) | 0% | 0 | Common Stock | |
| Lynn Seely | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 4,570 | 4,570 | - | - | Stock Option (Right to Buy) | |
| Lynn Seely | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 2,242 | 13,254 (0%) | 0% | 0 | Common Stock | |
| Daniella Beckman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 4,570 | 4,570 | - | - | Stock Option (Right to Buy) | |
| Daniella Beckman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 2,242 | 10,842 (0%) | 0% | 0 | Common Stock | |
| Jeffrey W. Albers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 4,570 | 4,570 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 2,242 | 167,259 (0%) | 0% | 0 | Common Stock | |
| Lonnel Coats | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 4,570 | 4,570 | - | - | Stock Option (Right to Buy) | |
| Lonnel Coats | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 2,242 | 13,254 (0%) | 0% | 0 | Common Stock | |
| Nicholas Lydon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 2,242 | 58,026 (0%) | 0% | 0 | Common Stock | |
| Nicholas Lydon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 4,570 | 4,570 | - | - | Stock Option (Right to Buy) | |
| Habib Joseph Dable | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 4,570 | 4,570 | - | - | Stock Option (Right to Buy) | |
| Habib Joseph Dable | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 2,242 | 8,742 (0%) | 0% | 0 | Common Stock | |
| John Tsai | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 2,242 | 8,742 (0%) | 0% | 0 | Common Stock | |
| John Tsai | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 4,570 | 4,570 | - | - | Stock Option (Right to Buy) | |
| Percy H. Carter | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 105.13 per share. | 05 Jun 2024 | 4,000 | 41,895 (0%) | 0% | 105.1 | 420,520 | Common Stock |
| Becker Hewes | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 104.91 per share. | 04 Jun 2024 | 2,424 | 29,514 (0%) | 0% | 104.9 | 254,302 | Common Stock |
| Percy H. Carter | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 106.43 per share. | 03 Jun 2024 | 2,436 | 45,895 (0%) | 0% | 106.4 | 259,263 | Common Stock |
| Becker Hewes | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.24 per share. | 31 May 2024 | 10,573 | 56,854 (0%) | 0% | 66.2 | 700,356 | Common Stock |
| Becker Hewes | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 May 2024 | 5,729 | 19,271 | - | - | Stock Options (Right to Buy) | |
| Becker Hewes | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 May 2024 | 8,385 | 9,115 | - | - | Stock Options (Right to Buy) | |
| Becker Hewes | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 May 2024 | 10,573 | 13,490 | - | - | Stock Options (Right to Buy) | |
| Becker Hewes | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 106.43 per share. | 31 May 2024 | 1,951 | 31,938 (0%) | 0% | 106.4 | 207,645 | Common Stock |
| Becker Hewes | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 106.43 per share. | 31 May 2024 | 2,971 | 33,889 (0%) | 0% | 106.4 | 316,204 | Common Stock |
| Becker Hewes | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 104.83 per share. | 31 May 2024 | 6,342 | 36,860 (0%) | 0% | 104.8 | 664,832 | Common Stock |
| Becker Hewes | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 105.81 per share. | 31 May 2024 | 20,904 | 43,202 (0%) | 0% | 105.8 | 2,211,852 | Common Stock |
| Becker Hewes | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 106.50 per share. | 31 May 2024 | 3,191 | 64,106 (0%) | 0% | 106.5 | 339,842 | Common Stock |
| Becker Hewes | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 107.86 per share. | 31 May 2024 | 3,671 | 67,297 (0%) | 0% | 107.9 | 395,954 | Common Stock |
| Becker Hewes | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 43.15 per share. | 31 May 2024 | 5,729 | 70,968 (0%) | 0% | 43.1 | 247,206 | Common Stock |
| Becker Hewes | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 61.31 per share. | 31 May 2024 | 8,385 | 65,239 (0%) | 0% | 61.3 | 514,084 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 107.17 per share. | 15 May 2024 | 2,486 | 72,981 (0%) | 0% | 107.2 | 266,425 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 106.56 per share. | 15 May 2024 | 1,364 | 71,617 (0%) | 0% | 106.6 | 145,348 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 May 2024 | 4,500 | 4,500 | - | - | Stock Option (Right to Buy) | |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 106.56 per share. | 15 May 2024 | 2,274 | 14,913 (0%) | 0% | 106.6 | 242,317 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 107.22 per share. | 15 May 2024 | 3,582 | 17,187 (0%) | 0% | 107.2 | 384,062 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 43.15 per share. | 15 May 2024 | 1,356 | 20,769 (0%) | 0% | 43.1 | 58,511 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share. | 15 May 2024 | 4,500 | 19,413 (0%) | 0% | 36.1 | 162,225 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 May 2024 | 1,356 | 9,494 | - | - | Stock Option (Right to Buy) | |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.80 per share. | 08 May 2024 | 1,818 | 75,467 (0%) | 0% | 8.8 | 15,998 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 May 2024 | 1,818 | 0 | - | - | Stock Option (Right to Buy) | |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 May 2024 | 26,363 | 0 | - | - | Stock Option (Right to Buy) | |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share. | 08 May 2024 | 26,363 | 73,649 (0%) | 0% | 1.9 | 49,299 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 May 2024 | 10,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 105.00 per share. | 02 May 2024 | 10,000 | 47,286 (0%) | 0% | 105 | 1,050,000 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share. | 02 May 2024 | 10,000 | 57,286 (0%) | 0% | 36.1 | 360,500 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 54.13 per share. | 02 May 2024 | 1,834 | 16,747 (0%) | 0% | 54.1 | 99,274 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 May 2024 | 1,843 | 5,503 | - | - | Stock Option (Right to Buy) | |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 103.88 per share. | 02 May 2024 | 1,834 | 14,913 (0%) | 0% | 103.9 | 190,516 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share. | 28 Mar 2024 | 5,000 | 52,286 (0%) | 0% | 36.1 | 180,250 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Mar 2024 | 5,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 95.00 per share. | 28 Mar 2024 | 5,000 | 47,286 (0%) | 0% | 95 | 475,000 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share. | 20 Mar 2024 | 15,073 | 191,123 (0%) | 0% | 1.9 | 28,187 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Mar 2024 | 10,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Mar 2024 | 15,073 | 0 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 89.12 per share. | 20 Mar 2024 | 1,367 | 176,050 (0%) | 0% | 89.1 | 121,827 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 88.60 per share. | 20 Mar 2024 | 6,285 | 177,417 (0%) | 0% | 88.6 | 556,851 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 87.26 per share. | 20 Mar 2024 | 8,440 | 183,702 (0%) | 0% | 87.3 | 736,474 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 86.46 per share. | 20 Mar 2024 | 6,251 | 192,142 (0%) | 0% | 86.5 | 540,461 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 85.22 per share. | 20 Mar 2024 | 2,730 | 198,393 (0%) | 0% | 85.2 | 232,651 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share. | 20 Mar 2024 | 10,000 | 201,123 (0%) | 0% | 15.0 | 150,100 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2024 | 5,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 88.08 per share. | 15 Mar 2024 | 1,638 | 49,753 (0%) | 0% | 88.1 | 144,275 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 87.09 per share. | 15 Mar 2024 | 4,629 | 51,391 (0%) | 0% | 87.1 | 403,140 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 88.88 per share. | 15 Mar 2024 | 912 | 56,020 (0%) | 0% | 88.9 | 81,059 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 88.27 per share. | 15 Mar 2024 | 1,413 | 56,932 (0%) | 0% | 88.3 | 124,726 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 87.10 per share. | 15 Mar 2024 | 2,675 | 58,345 (0%) | 0% | 87.1 | 232,993 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share. | 15 Mar 2024 | 5,000 | 61,020 (0%) | 0% | 36.1 | 180,250 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 88.94 per share. | 15 Mar 2024 | 2,467 | 47,286 (0%) | 0% | 88.9 | 219,415 | Common Stock |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 89.88 per share. | 13 Mar 2024 | 1,800 | 34,729 (0%) | 0% | 89.9 | 161,784 | Common Stock |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 90.55 per share. | 13 Mar 2024 | 6,223 | 36,529 (0%) | 0% | 90.6 | 563,493 | Common Stock |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share. | 13 Mar 2024 | 1,224 | 42,752 (0%) | 0% | 15.0 | 18,372 | Common Stock |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.80 per share. | 13 Mar 2024 | 523 | 41,528 (0%) | 0% | 8.8 | 4,602 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 90.69 per share. | 07 Mar 2024 | 5,003 | 56,020 (0%) | 0% | 90.7 | 453,722 | Common Stock |
| Kathryn Haviland | CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 90.69 per share. | 07 Mar 2024 | 12,464 | 153,177 (0%) | 0% | 90.7 | 1,130,360 | Common Stock |
| Tracey L. McCain | EVP AND CHIEF LEGAL OFFICER | Sale of securities on an exchange or to another person at price $ 90.69 per share. | 07 Mar 2024 | 5,194 | 60,498 (0%) | 0% | 90.7 | 471,044 | Common Stock |
| Christopher K. Murray | CHIEF TECHNICAL OPERATIONS | Sale of securities on an exchange or to another person at price $ 90.69 per share. | 07 Mar 2024 | 2,521 | 33,853 (0%) | 0% | 90.7 | 228,629 | Common Stock |
| Christina Rossi | CHIEF OPERATING OFFICER | Sale of securities on an exchange or to another person at price $ 90.69 per share. | 07 Mar 2024 | 6,070 | 64,306 (0%) | 0% | 90.7 | 550,488 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 90.69 per share. | 07 Mar 2024 | 1,462 | 17,862 (0%) | 0% | 90.7 | 132,589 | Common Stock |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Sale of securities on an exchange or to another person at price $ 90.69 per share. | 07 Mar 2024 | 5,093 | 57,585 (0%) | 0% | 90.7 | 461,884 | Common Stock |
| Fouad Namouni | PRESIDENT, R & D | Sale of securities on an exchange or to another person at price $ 90.69 per share. | 07 Mar 2024 | 4,377 | 72,703 (0%) | 0% | 90.7 | 396,950 | Common Stock |
| Becker Hewes | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 90.69 per share. | 07 Mar 2024 | 3,097 | 46,281 (0%) | 0% | 90.7 | 280,867 | Common Stock |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 90.69 per share. | 07 Mar 2024 | 2,934 | 41,005 (0%) | 0% | 90.7 | 266,084 | Common Stock |
| Percy H. Carter | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 90.69 per share. | 07 Mar 2024 | 2,286 | 48,331 (0%) | 0% | 90.7 | 207,317 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 90.69 per share. | 07 Mar 2024 | 11,033 | 165,017 (0%) | 0% | 90.7 | 1,000,583 | Common Stock |
| Christopher K. Murray | CHIEF TECHNICAL OPERATIONS | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 12,500 | 36,995 (0%) | 0% | 0 | Common Stock | |
| Christopher K. Murray | CHIEF TECHNICAL OPERATIONS | Sale of securities on an exchange or to another person at price $ 93.65 per share. | 01 Mar 2024 | 621 | 36,374 (0%) | 0% | 93.7 | 58,157 | Common Stock |
| Christopher K. Murray | CHIEF TECHNICAL OPERATIONS | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 12,500 | 61,023 (0%) | 0% | 0 | Common Stock | |
| Kathryn Haviland | CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 40,000 | 165,641 (0%) | 0% | 0 | Common Stock | |
| Kathryn Haviland | CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 80,000 | 80,000 | - | - | Stock Option (Right to Buy) | |
| Tracey L. McCain | EVP AND CHIEF LEGAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Tracey L. McCain | EVP AND CHIEF LEGAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 12,500 | 65,692 (0%) | 0% | 0 | Common Stock | |
| Christina Rossi | CHIEF OPERATING OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 15,000 | 70,376 (0%) | 0% | 0 | Common Stock | |
| Christina Rossi | CHIEF OPERATING OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 5,000 | 19,324 (0%) | 0% | 0 | Common Stock | |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 12,500 | 62,678 (0%) | 0% | 0 | Common Stock | |
| Fouad Namouni | PRESIDENT, R & D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Fouad Namouni | PRESIDENT, R & D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 15,000 | 77,080 (0%) | 0% | 0 | Common Stock | |
| Becker Hewes | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 25,000 | 25,000 | - | - | Stock Options (Right to Buy) | |
| Becker Hewes | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 12,500 | 49,378 (0%) | 0% | 0 | Common Stock | |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 12,500 | 43,939 (0%) | 0% | 0 | Common Stock | |
| Percy H. Carter | CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Percy H. Carter | CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 12,500 | 50,617 (0%) | 0% | 0 | Common Stock | |
| K. Christopher Murray | CHIEF TECHNICAL OPERATIONS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2024 | 5,000 | 8,000 | - | - | Stock Option (Right to Buy) | |
| K. Murray Christopher | CHIEF TECHNICAL OPERATIONS | Sale of securities on an exchange or to another person at price $ 100.00 per share. | 28 Feb 2024 | 5,000 | 24,495 (0%) | 0% | 100 | 500,000 | Common Stock |
| Christopher K. Murray | CHIEF TECHNICAL OPERATIONS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 54.13 per share. | 28 Feb 2024 | 5,000 | 29,495 (0%) | 0% | 54.1 | 270,650 | Common Stock |
| Albers W. Jeffrey | Director | Sale of securities on an exchange or to another person at price $ 83.57 per share. | 25 Jan 2024 | 100 | 176,050 (0%) | 0% | 83.6 | 8,357 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 81.70 per share. | 25 Jan 2024 | 10,890 | 184,074 (0%) | 0% | 81.7 | 889,713 | Common Stock |
| Jeffrey Albers W. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jan 2024 | 15,000 | 15,073 | - | - | Stock Option (Right to Buy) | |
| Jeffrey Albers W. | Director | Sale of securities on an exchange or to another person at price $ 81.16 per share. | 25 Jan 2024 | 6,086 | 194,964 (0%) | 0% | 81.2 | 493,940 | Common Stock |
| Albers Jeffrey W. | Director | Sale of securities on an exchange or to another person at price $ 82.76 per share. | 25 Jan 2024 | 7,924 | 176,150 (0%) | 0% | 82.8 | 655,790 | Common Stock |
| Albers Jeffrey W. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jan 2024 | 10,000 | 2,496 | - | - | Stock Option (Right to Buy) | |
| W. Jeffrey Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share. | 25 Jan 2024 | 15,000 | 191,050 (0%) | 0% | 1.9 | 28,050 | Common Stock |
| Jeffrey Albers W. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share. | 25 Jan 2024 | 10,000 | 201,050 (0%) | 0% | 15.0 | 150,100 | Common Stock |
| Hurley Ariel | PRINCIPAL ACCOUNTING OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Dec 2023 | 714 | 0 | - | - | Stock Option (Right to Buy) | |
| Hurley Ariel | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 90.00 per share. | 22 Dec 2023 | 714 | 14,324 (0%) | 0% | 90 | 64,260 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.80 per share. | 22 Dec 2023 | 714 | 15,038 (0%) | 0% | 8.8 | 6,283 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 84.35 per share. | 15 Dec 2023 | 260 | 14,324 (0%) | 0% | 84.4 | 21,931 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 84.35 per share. | 15 Dec 2023 | 1,827 | 14,584 (0%) | 0% | 84.3 | 154,107 | Common Stock |
| Hurley Ariel | PRINCIPAL ACCOUNTING OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share. | 15 Dec 2023 | 1,827 | 16,411 (0%) | 0% | 1.9 | 3,416 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share. | 15 Dec 2023 | 1,827 | 16,411 (0%) | 0% | 1.9 | 3,416 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 84.35 per share. | 15 Dec 2023 | 1,827 | 14,584 (0%) | 0% | 84.3 | 154,107 | Common Stock |
| Hurley Ariel | PRINCIPAL ACCOUNTING OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Dec 2023 | 3,654 | 0 | - | - | Stock Option (Right to Buy) | |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share. | 13 Dec 2023 | 261 | 31,439 (0%) | 0% | 1.9 | 488 | Common Stock |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2023 | 261 | 0 | - | - | Stock Option (Right to Buy) | |
| Albers Jeffrey W. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Dec 2023 | 5,000 | 150,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share. | 11 Dec 2023 | 5,000 | 181,050 (0%) | 0% | 36.1 | 180,250 | Common Stock |
| W. Jeffrey Albers | Director | Sale of securities on an exchange or to another person at price $ 79.07 per share. | 11 Dec 2023 | 5,000 | 176,050 (0%) | 0% | 79.1 | 395,350 | Common Stock |
| Christopher Murray K. | CHIEF TECHNICAL OPERATIONS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Dec 2023 | 5,000 | 13,000 | - | - | Stock Option (Right to Buy) | |
| K. Christopher Murray | CHIEF TECHNICAL OPERATIONS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 54.13 per share. | 07 Dec 2023 | 5,000 | 29,495 (0%) | 0% | 54.1 | 270,650 | Common Stock |
| Christopher K. Murray | CHIEF TECHNICAL OPERATIONS | Sale of securities on an exchange or to another person at price $ 75.00 per share. | 07 Dec 2023 | 5,000 | 24,495 (0%) | 0% | 75 | 375,000 | Common Stock |
| K. Christopher Murray | CHIEF TECHNICAL OPERATIONS | Sale of securities on an exchange or to another person at price $ 71.43 per share. | 04 Dec 2023 | 600 | 24,495 (0%) | 0% | 71.4 | 42,858 | Common Stock |
| Albers W. Jeffrey | Director | Sale of securities on an exchange or to another person at price $ 70.55 per share. | 30 Nov 2023 | 5,000 | 176,050 (0%) | 0% | 70.6 | 352,750 | Common Stock |
| Albers Jeffrey W. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Nov 2023 | 5,000 | 155,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share. | 30 Nov 2023 | 5,000 | 181,050 (0%) | 0% | 36.1 | 180,250 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 67.25 per share. | 24 Nov 2023 | 7,964 | 183,086 (0%) | 0% | 67.3 | 535,579 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Nov 2023 | 15,000 | 30,073 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 67.81 per share. | 24 Nov 2023 | 7,036 | 176,050 (0%) | 0% | 67.8 | 477,111 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share. | 24 Nov 2023 | 15,000 | 191,050 (0%) | 0% | 1.9 | 28,050 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share. | 01 Nov 2023 | 1,485 | 177,535 (0%) | 0% | 36.0 | 53,534 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2023 | 1,485 | 160,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2023 | 4,634 | 161,485 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2023 | 3,881 | 166,119 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 60.13 per share. | 01 Nov 2023 | 1,485 | 176,050 (0%) | 0% | 60.1 | 89,293 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 61.05 per share. | 01 Nov 2023 | 59 | 176,050 (0%) | 0% | 61.1 | 3,602 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 60.36 per share. | 01 Nov 2023 | 4,575 | 176,109 (0%) | 0% | 60.4 | 276,147 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share. | 01 Nov 2023 | 4,634 | 180,684 (0%) | 0% | 36.1 | 167,056 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 60.02 per share. | 01 Nov 2023 | 3,881 | 176,050 (0%) | 0% | 60.0 | 232,938 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share. | 01 Nov 2023 | 3,881 | 179,931 (0%) | 0% | 36.0 | 139,910 | Common Stock |
| Christopher K. Murray | CHIEF TECHNICAL OPERATIONS | Sale of securities on an exchange or to another person at price $ 56.40 per share. | 26 Oct 2023 | 600 | 25,095 (0%) | 0% | 56.4 | 33,840 | Common Stock |
| Fouad Namouni | PRESIDENT, R & D | Sale of securities on an exchange or to another person at price $ 48.06 per share. | 04 Oct 2023 | 3,769 | 62,080 (0%) | 0% | 48.1 | 181,138 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Sep 2023 | 18,102 | 51,971 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 50.17 per share. | 27 Sep 2023 | 6,898 | 176,050 (0%) | 0% | 50.2 | 346,073 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share. | 27 Sep 2023 | 6,898 | 182,948 (0%) | 0% | 1.9 | 12,899 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 50.50 per share. | 27 Sep 2023 | 400 | 176,050 (0%) | 0% | 50.5 | 20,200 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 49.93 per share. | 27 Sep 2023 | 12,102 | 176,450 (0%) | 0% | 49.9 | 604,253 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share. | 27 Sep 2023 | 18,102 | 194,152 (0%) | 0% | 1.9 | 33,851 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 48.84 per share. | 27 Sep 2023 | 5,600 | 188,552 (0%) | 0% | 48.8 | 273,504 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Sep 2023 | 6,898 | 45,073 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share. | 24 Aug 2023 | 10,000 | 186,050 (0%) | 0% | 1.9 | 18,700 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Aug 2023 | 15,000 | 80,073 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 50.16 per share. | 24 Aug 2023 | 10,000 | 176,050 (0%) | 0% | 50.2 | 501,600 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share. | 24 Aug 2023 | 15,000 | 191,050 (0%) | 0% | 1.9 | 28,050 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 49.57 per share. | 24 Aug 2023 | 15,000 | 176,050 (0%) | 0% | 49.6 | 743,550 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Aug 2023 | 10,000 | 70,073 | - | - | Stock Option (Right to Buy) | |
| Alexis A. Borisy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2023 | 2,600 | 71,918 (0%) | 0% | 0 | Common Stock | |
| Alexis A. Borisy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2023 | 5,300 | 5,300 | - | - | Stock Option (Right to Buy) | |
| Mark Alan Goldberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2023 | 2,600 | 16,012 (0%) | 0% | 0 | Common Stock | |
| Mark Alan Goldberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2023 | 5,300 | 5,300 | - | - | Stock Option (Right to Buy) | |
| Lynn Seely | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2023 | 2,600 | 11,012 (0%) | 0% | 0 | Common Stock | |
| Lynn Seely | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2023 | 5,300 | 5,300 | - | - | Stock Option (Right to Buy) | |
| Daniella Beckman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2023 | 2,600 | 8,600 (0%) | 0% | 0 | Common Stock | |
| Daniella Beckman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2023 | 5,300 | 5,300 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2023 | 5,300 | 5,300 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2023 | 2,600 | 176,050 (0%) | 0% | 0 | Common Stock | |
| Lonnel Coats | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2023 | 2,600 | 11,012 (0%) | 0% | 0 | Common Stock | |
| Nicholas Lydon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2023 | 5,300 | 5,300 | - | - | Stock Option (Right to Buy) | |
| Nicholas Lydon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2023 | 2,600 | 55,784 (0%) | 0% | 0 | Common Stock | |
| Habib J. Dable | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2023 | 2,600 | 6,500 (0%) | 0% | 0 | Common Stock | |
| Habib J. Dable | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2023 | 5,300 | 5,300 | - | - | Stock Option (Right to Buy) | |
| John Tsai | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2023 | 2,600 | 6,500 (0%) | 0% | 0 | Common Stock | |
| John Tsai | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2023 | 5,300 | 5,300 | - | - | Stock Option (Right to Buy) | |
| Becker Hewes | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 52.05 per share. | 05 Jun 2023 | 1,404 | 36,878 (0%) | 0% | 52.0 | 73,078 | Common Stock |
| Percy H. Carter | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 52.06 per share. | 05 Jun 2023 | 2,307 | 38,117 (0%) | 0% | 52.1 | 120,102 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 1,600 | 1,600 | - | - | Stock Option (Right to Buy) | |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 87.28 per share. | 15 Mar 2023 | 2,949 | 14,913 (0%) | 0% | 87.3 | 257,389 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 90.00 per share. | 15 Mar 2023 | 800 | 17,862 (0%) | 0% | 90 | 72,000 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share. | 15 Mar 2023 | 800 | 18,662 (0%) | 0% | 15.0 | 12,008 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 87.28 per share. | 15 Mar 2023 | 800 | 17,862 (0%) | 0% | 87.3 | 69,824 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share. | 15 Mar 2023 | 800 | 18,662 (0%) | 0% | 15.0 | 12,008 | Common Stock |
| Tracey L. McCain | EVP AND CHIEF LEGAL OFFICER | Sale of securities on an exchange or to another person at price $ 45.72 per share. | 06 Mar 2023 | 3,216 | 52,772 (0%) | 0% | 45.7 | 147,036 | Common Stock |
| Tracey L. McCain | EVP AND CHIEF LEGAL OFFICER | Sale of securities on an exchange or to another person at price $ 44.41 per share. | 06 Mar 2023 | 106 | 52,666 (0%) | 0% | 44.4 | 4,707 | Common Stock |
| Christopher K. Murray | CHIEF TECHNICAL OPERATIONS | Sale of securities on an exchange or to another person at price $ 45.71 per share. | 06 Mar 2023 | 1,829 | 25,741 (0%) | 0% | 45.7 | 83,604 | Common Stock |
| Christopher K. Murray | CHIEF TECHNICAL OPERATIONS | Sale of securities on an exchange or to another person at price $ 44.30 per share. | 06 Mar 2023 | 46 | 25,695 (0%) | 0% | 44.3 | 2,038 | Common Stock |
| Christina Rossi | CHIEF OPERATING OFFICER | Sale of securities on an exchange or to another person at price $ 45.72 per share. | 06 Mar 2023 | 2,960 | 55,475 (0%) | 0% | 45.7 | 135,331 | Common Stock |
| Christina Rossi | CHIEF OPERATING OFFICER | Sale of securities on an exchange or to another person at price $ 44.28 per share. | 06 Mar 2023 | 99 | 55,376 (0%) | 0% | 44.3 | 4,384 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 45.72 per share. | 06 Mar 2023 | 1,091 | 14,210 (0%) | 0% | 45.7 | 49,881 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 44.40 per share. | 06 Mar 2023 | 35 | 14,175 (0%) | 0% | 44.4 | 1,554 | Common Stock |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Sale of securities on an exchange or to another person at price $ 45.71 per share. | 06 Mar 2023 | 3,084 | 50,252 (0%) | 0% | 45.7 | 140,970 | Common Stock |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Sale of securities on an exchange or to another person at price $ 44.30 per share. | 06 Mar 2023 | 74 | 50,178 (0%) | 0% | 44.3 | 3,278 | Common Stock |
| Fouad Namouni | PRESIDENT, R & D | Sale of securities on an exchange or to another person at price $ 44.37 per share. | 06 Mar 2023 | 63 | 65,849 (0%) | 0% | 44.4 | 2,795 | Common Stock |
| Fouad Namouni | PRESIDENT, R & D | Sale of securities on an exchange or to another person at price $ 45.72 per share. | 06 Mar 2023 | 1,885 | 65,912 (0%) | 0% | 45.7 | 86,182 | Common Stock |
| Becker Hewes | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 45.72 per share. | 06 Mar 2023 | 1,466 | 38,330 (0%) | 0% | 45.7 | 67,026 | Common Stock |
| Becker Hewes | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 44.77 per share. | 06 Mar 2023 | 48 | 38,282 (0%) | 0% | 44.8 | 2,149 | Common Stock |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 45.72 per share. | 06 Mar 2023 | 1,622 | 31,232 (0%) | 0% | 45.7 | 74,158 | Common Stock |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 44.41 per share. | 06 Mar 2023 | 54 | 31,178 (0%) | 0% | 44.4 | 2,398 | Common Stock |
| Percy H. Carter | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 45.72 per share. | 06 Mar 2023 | 736 | 40,449 (0%) | 0% | 45.7 | 33,650 | Common Stock |
| Percy H. Carter | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 44.80 per share. | 06 Mar 2023 | 25 | 40,424 (0%) | 0% | 44.8 | 1,120 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 44.27 per share. | 06 Mar 2023 | 319 | 173,450 (0%) | 0% | 44.3 | 14,122 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 45.72 per share. | 06 Mar 2023 | 9,474 | 173,769 (0%) | 0% | 45.7 | 433,151 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 44.48 per share. | 06 Mar 2023 | 96 | 48,523 (0%) | 0% | 44.5 | 4,270 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 45.72 per share. | 06 Mar 2023 | 2,911 | 48,619 (0%) | 0% | 45.7 | 133,091 | Common Stock |
| Kathryn Haviland | CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 44.65 per share. | 06 Mar 2023 | 212 | 125,641 (0%) | 0% | 44.7 | 9,466 | Common Stock |
| Kathryn Haviland | CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 45.72 per share. | 06 Mar 2023 | 6,428 | 125,853 (0%) | 0% | 45.7 | 293,888 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 12,500 | 51,530 (0%) | 0% | 0 | Common Stock | |
| Kathryn Haviland | CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 80,000 | 80,000 | - | - | Stock Option (Right to Buy) | |
| Kathryn Haviland | CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 40,000 | 132,281 (0%) | 0% | 0 | Common Stock | |
| Tracey L. McCain | EVP AND CHIEF LEGAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Tracey L. McCain | EVP AND CHIEF LEGAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 12,500 | 55,988 (0%) | 0% | 0 | Common Stock | |
| Christopher K. Murray | CHIEF TECHNICAL OPERATIONS | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 8,750 | 27,570 (0%) | 0% | 0 | Common Stock | |
| Christopher K. Murray | CHIEF TECHNICAL OPERATIONS | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 17,500 | 17,500 | - | - | Stock Option (Right to Buy) | |
| Christina Rossi | CHIEF OPERATING OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Christina Rossi | CHIEF OPERATING OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 15,000 | 58,435 (0%) | 0% | 0 | Common Stock | |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 10,850 | 10,850 | - | - | Stock Option (Right to Buy) | |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 5,425 | 15,301 (0%) | 0% | 0 | Common Stock | |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 12,500 | 53,336 (0%) | 0% | 0 | Common Stock | |
| Fouad Namouni | PRESIDENT, R & D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 15,000 | 67,797 (0%) | 0% | 0 | Common Stock | |
| Fouad Namouni | PRESIDENT, R & D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Becker Hewes | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 12,500 | 39,796 (0%) | 0% | 0 | Common Stock | |
| Becker Hewes | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 25,000 | 25,000 | - | - | Stock Options (Right to Buy) | |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Philina Lee | CHIEF COMMERCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 12,500 | 32,854 (0%) | 0% | 0 | Common Stock | |
| Percy H. Carter | CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 12,500 | 41,185 (0%) | 0% | 0 | Common Stock | |
| Percy H. Carter | CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| John Tsai | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2023 | 3,900 | 3,900 (0%) | 0% | 0 | Common Stock | |
| John Tsai | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2023 | 7,950 | 7,950 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 50.09 per share. | 05 Dec 2022 | 20,000 | 183,243 (0%) | 0% | 50.1 | 1,001,800 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2022 | 10,000 | 95,073 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2022 | 10,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share. | 05 Dec 2022 | 10,000 | 193,243 (0%) | 0% | 1.9 | 18,700 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share. | 05 Dec 2022 | 10,000 | 203,243 (0%) | 0% | 15.0 | 150,100 | Common Stock |
| Kathryn Haviland | CHIEF EXECUTIVE OFFICER | Purchase of securities on an exchange or from another person at price $ 43.98 per share. | 03 Nov 2022 | 1,100 | 92,281 (0%) | 0% | 44.0 | 48,378 | Common Stock |
| Christina Rossi | CHIEF OPERATING OFFICER | Sale of securities on an exchange or to another person at price $ 45.24 per share. | 03 Nov 2022 | 533 | 43,435 (0%) | 0% | 45.2 | 24,113 | Common Stock |
| Fouad Namouni | PRESIDENT, R & D | Sale of securities on an exchange or to another person at price $ 67.30 per share. | 04 Oct 2022 | 3,477 | 52,797 (0%) | 0% | 67.3 | 234,002 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 70.02 per share. | 19 Aug 2022 | 1,590 | 183,243 (0%) | 0% | 70.0 | 111,332 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Aug 2022 | 8,410 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Aug 2022 | 1,590 | 38,410 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 71.30 per share. | 19 Aug 2022 | 662 | 183,243 (0%) | 0% | 71.3 | 47,201 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 70.47 per share. | 19 Aug 2022 | 7,748 | 183,905 (0%) | 0% | 70.5 | 546,002 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share. | 19 Aug 2022 | 8,410 | 191,653 (0%) | 0% | 15.0 | 126,234 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share. | 19 Aug 2022 | 1,590 | 184,833 (0%) | 0% | 15.0 | 23,866 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share. | 16 Aug 2022 | 10,000 | 203,243 (0%) | 0% | 15.0 | 150,100 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Aug 2022 | 10,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Aug 2022 | 10,000 | 105,073 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 69.52 per share. | 16 Aug 2022 | 293 | 183,243 (0%) | 0% | 69.5 | 20,369 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 68.62 per share. | 16 Aug 2022 | 12,477 | 183,536 (0%) | 0% | 68.6 | 856,172 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 68.01 per share. | 16 Aug 2022 | 7,230 | 196,013 (0%) | 0% | 68.0 | 491,712 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share. | 16 Aug 2022 | 10,000 | 193,243 (0%) | 0% | 1.9 | 18,700 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share. | 08 Aug 2022 | 2,830 | 193,243 (0%) | 0% | 1.9 | 5,292 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Aug 2022 | 2,830 | 115,073 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Aug 2022 | 7,170 | 0 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 70.07 per share. | 08 Aug 2022 | 10,000 | 183,243 (0%) | 0% | 70.1 | 700,700 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.80 per share. | 08 Aug 2022 | 7,170 | 190,413 (0%) | 0% | 8.8 | 63,096 | Common Stock |
| Christopher K. Murray | SVP, TECHNICAL OPERATIONS | Sale of securities on an exchange or to another person at price $ 65.00 per share. | 04 Aug 2022 | 2,500 | 18,820 (0%) | 0% | 65 | 162,500 | Common Stock |
| Christopher K. Murray | SVP, TECHNICAL OPERATIONS | Sale of securities on an exchange or to another person at price $ 60.44 per share. | 04 Aug 2022 | 2,500 | 21,320 (0%) | 0% | 60.4 | 151,100 | Common Stock |
| Habib J. Dable | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jun 2022 | 3,900 | 3,900 (0%) | 0% | 0 | Common Stock | |
| Habib J. Dable | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jun 2022 | 7,950 | 7,950 | - | - | Stock Option (Right to Buy) | |
| Alexis A. Borisy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2022 | 2,600 | 69,318 (0%) | 0% | 0 | Common Stock | |
| Mark Alan Goldberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2022 | 2,600 | 13,412 (0%) | 0% | 0 | Common Stock | |
| Mark Alan Goldberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2022 | 5,300 | 5,300 | - | - | Stock Option (Right to Buy) | |
| Lynn Seely | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2022 | 2,600 | 8,412 (0%) | 0% | 0 | Common Stock | |
| Lynn Seely | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2022 | 5,300 | 5,300 | - | - | Stock Option (Right to Buy) | |
| Daniella Beckman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2022 | 2,600 | 6,000 (0%) | 0% | 0 | Common Stock | |
| Daniella Beckman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2022 | 5,300 | 5,300 | - | - | Stock Option (Right to Buy) | |
| Lonnel Coats | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2022 | 2,600 | 8,412 (0%) | 0% | 0 | Common Stock | |
| Lonnel Coats | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2022 | 5,300 | 5,300 | - | - | Stock Option (Right to Buy) | |
| George D. Demetri | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2022 | 5,300 | 5,300 | - | - | Stock Option (Right to Buy) | |
| George D. Demetri | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2022 | 2,600 | 8,412 (0%) | 0% | 0 | Common Stock | |
| George D. Demetri | Director | Sale of securities on an exchange or to another person at price $ 58.60 per share. | 21 Jun 2022 | 10 | 5,812 (0%) | 0% | 58.6 | 586 | Common Stock |
| George D. Demetri | Director | Purchase of securities on an exchange or from another person at price $ 82.70 per share. | 21 Jun 2022 | 10 | 5,822 (0%) | 0% | 82.7 | 827 | Common Stock |
| Nicholas Lydon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2022 | 2,600 | 53,184 (0%) | 0% | 0 | Common Stock | |
| Nicholas Lydon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2022 | 5,300 | 5,300 | - | - | Stock Option (Right to Buy) | |
| Becker Hewes | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 59.76 per share. | 06 Jun 2022 | 1,220 | 30,451 (0%) | 0% | 59.8 | 72,907 | Common Stock |
| Becker Hewes | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 60.00 per share. | 06 Jun 2022 | 3,155 | 27,296 (0%) | 0% | 60 | 189,300 | Common Stock |
| Percy H. Carter | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 59.76 per share. | 06 Jun 2022 | 1,908 | 28,685 (0%) | 0% | 59.8 | 114,022 | Common Stock |
| Nicholas Lydon | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 May 2022 | 10,909 | 0 | - | - | Stock Option (Right to Buy) | |
| Nicholas Lydon | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.53 per share. | 23 May 2022 | 10,909 | 50,584 (0%) | 0% | 19.5 | 213,053 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 54.48 per share. | 16 May 2022 | 1,900 | 201,343 (0%) | 0% | 54.5 | 103,512 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share. | 16 May 2022 | 10,000 | 203,243 (0%) | 0% | 15.0 | 150,100 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share. | 16 May 2022 | 10,000 | 193,243 (0%) | 0% | 1.9 | 18,700 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2022 | 10,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2022 | 10,000 | 117,903 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 56.21 per share. | 16 May 2022 | 12,758 | 183,243 (0%) | 0% | 56.2 | 717,127 | Common Stock |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 55.63 per share. | 16 May 2022 | 5,342 | 196,001 (0%) | 0% | 55.6 | 297,175 | Common Stock |
| Jeffrey W. Albers | Director, CEO AND PRESIDENT | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share. | 06 Apr 2022 | 5,000 | 188,243 (0%) | 0% | 15.0 | 75,050 | Common Stock |
| Jeffrey W. Albers | Director, CEO AND PRESIDENT | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Apr 2022 | 5,000 | 60,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director, CEO AND PRESIDENT | Sale of securities on an exchange or to another person at price $ 70.11 per share. | 06 Apr 2022 | 5,000 | 183,243 (0%) | 0% | 70.1 | 350,550 | Common Stock |
| Becker Hewes | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 60.00 per share. | 16 Mar 2022 | 2,219 | 31,671 (0%) | 0% | 60 | 133,140 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 57.15 per share. | 10 Mar 2022 | 2,339 | 9,616 (0%) | 0% | 57.2 | 133,674 | Common Stock |
| Fouad Namouni | PRESIDENT, R & D | Sale of securities on an exchange or to another person at price $ 56.19 per share. | 07 Mar 2022 | 1,047 | 56,274 (0%) | 0% | 56.2 | 58,831 | Common Stock |
| Becker Hewes | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 56.19 per share. | 07 Mar 2022 | 1,047 | 33,890 (0%) | 0% | 56.2 | 58,831 | Common Stock |
| Mark Alan Goldberg | Director | Purchase of securities on an exchange or from another person at price $ 59.98 per share. | 03 Mar 2022 | 5,000 | 10,812 (0%) | 0% | 60.0 | 299,900 | Common Stock |
| Jeffrey W. Albers | Director, CEO AND PRESIDENT | Sale of securities on an exchange or to another person at price $ 60.28 per share. | 03 Mar 2022 | 7,862 | 188,086 (0%) | 0% | 60.3 | 473,921 | Common Stock |
| Jeffrey W. Albers | Director, CEO AND PRESIDENT | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2022 | 12,500 | 65,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director, CEO AND PRESIDENT | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2022 | 7,500 | 127,903 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director, CEO AND PRESIDENT | Sale of securities on an exchange or to another person at price $ 56.19 per share. | 03 Mar 2022 | 4,843 | 183,243 (0%) | 0% | 56.2 | 272,128 | Common Stock |
| Jeffrey W. Albers | Director, CEO AND PRESIDENT | Sale of securities on an exchange or to another person at price $ 59.43 per share. | 03 Mar 2022 | 1,400 | 188,086 (0%) | 0% | 59.4 | 83,202 | Common Stock |
| Jeffrey W. Albers | Director, CEO AND PRESIDENT | Sale of securities on an exchange or to another person at price $ 58.28 per share. | 03 Mar 2022 | 4,100 | 189,486 (0%) | 0% | 58.3 | 238,948 | Common Stock |
| Jeffrey W. Albers | Director, CEO AND PRESIDENT | Sale of securities on an exchange or to another person at price $ 57.66 per share. | 03 Mar 2022 | 4,445 | 193,586 (0%) | 0% | 57.7 | 256,299 | Common Stock |
| Jeffrey W. Albers | Director, CEO AND PRESIDENT | Sale of securities on an exchange or to another person at price $ 56.61 per share. | 03 Mar 2022 | 10,055 | 198,031 (0%) | 0% | 56.6 | 569,214 | Common Stock |
| Jeffrey W. Albers | Director, CEO AND PRESIDENT | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share. | 03 Mar 2022 | 12,500 | 208,086 (0%) | 0% | 15.0 | 187,625 | Common Stock |
| Jeffrey W. Albers | Director, CEO AND PRESIDENT | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share. | 03 Mar 2022 | 7,500 | 195,586 (0%) | 0% | 1.9 | 14,025 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 56.19 per share. | 03 Mar 2022 | 1,047 | 39,030 (0%) | 0% | 56.2 | 58,831 | Common Stock |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 60.27 per share. | 03 Mar 2022 | 1,328 | 40,077 (0%) | 0% | 60.3 | 80,039 | Common Stock |
| Kathryn Haviland | CHIEF OPERATING OFFICER | Sale of securities on an exchange or to another person at price $ 56.18 per share. | 03 Mar 2022 | 1,048 | 91,181 (0%) | 0% | 56.2 | 58,877 | Common Stock |
| Kathryn Haviland | CHIEF OPERATING OFFICER | Sale of securities on an exchange or to another person at price $ 60.27 per share. | 03 Mar 2022 | 1,719 | 92,229 (0%) | 0% | 60.3 | 103,604 | Common Stock |
| Tracey McCain | EVP AND CHIEF LEGAL OFFICER | Sale of securities on an exchange or to another person at price $ 56.19 per share. | 03 Mar 2022 | 1,047 | 43,227 (0%) | 0% | 56.2 | 58,831 | Common Stock |
| Tracey McCain | EVP AND CHIEF LEGAL OFFICER | Sale of securities on an exchange or to another person at price $ 60.28 per share. | 03 Mar 2022 | 1,667 | 44,274 (0%) | 0% | 60.3 | 100,487 | Common Stock |
| Christopher K. Murray | SVP, TECHNICAL OPERATIONS | Sale of securities on an exchange or to another person at price $ 56.19 per share. | 03 Mar 2022 | 502 | 23,820 (0%) | 0% | 56.2 | 28,207 | Common Stock |
| Christopher K. Murray | SVP, TECHNICAL OPERATIONS | Sale of securities on an exchange or to another person at price $ 60.27 per share. | 03 Mar 2022 | 1,066 | 24,322 (0%) | 0% | 60.3 | 64,248 | Common Stock |
| Christina Rossi | CHIEF COMMERCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 56.19 per share. | 03 Mar 2022 | 1,047 | 44,479 (0%) | 0% | 56.2 | 58,831 | Common Stock |
| Christina Rossi | CHIEF COMMERCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 60.28 per share. | 03 Mar 2022 | 1,197 | 45,526 (0%) | 0% | 60.3 | 72,155 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 56.19 per share. | 03 Mar 2022 | 256 | 11,955 (0%) | 0% | 56.2 | 14,385 | Common Stock |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Sale of securities on an exchange or to another person at price $ 60.27 per share. | 03 Mar 2022 | 761 | 12,211 (0%) | 0% | 60.3 | 45,865 | Common Stock |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Sale of securities on an exchange or to another person at price $ 56.19 per share. | 03 Mar 2022 | 1,047 | 40,836 (0%) | 0% | 56.2 | 58,831 | Common Stock |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Sale of securities on an exchange or to another person at price $ 60.27 per share. | 03 Mar 2022 | 1,491 | 41,883 (0%) | 0% | 60.3 | 89,863 | Common Stock |
| Jeffrey W. Albers | Director, CEO AND PRESIDENT | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 7,500 | 195,948 (0%) | 0% | 0 | Common Stock | |
| Jeffrey W. Albers | Director, CEO AND PRESIDENT | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Michael Landsittel | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 12,500 | 41,405 (0%) | 0% | 0 | Common Stock | |
| Kathryn Haviland | CHIEF OPERATING OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 80,000 | 80,000 | - | - | Stock Option (Right to Buy) | |
| Kathryn Haviland | CHIEF OPERATING OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 40,000 | 93,948 (0%) | 0% | 0 | Common Stock | |
| Tracey McCain | EVP AND CHIEF LEGAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Tracey McCain | EVP AND CHIEF LEGAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 12,500 | 45,941 (0%) | 0% | 0 | Common Stock | |
| Christopher K. Murray | SVP, TECHNICAL OPERATIONS | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 6,500 | 25,388 (0%) | 0% | 0 | Common Stock | |
| Christopher K. Murray | SVP, TECHNICAL OPERATIONS | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 13,000 | 13,000 | - | - | Stock Option (Right to Buy) | |
| Christina Rossi | CHIEF COMMERCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Christina Rossi | CHIEF COMMERCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 15,000 | 46,723 (0%) | 0% | 0 | Common Stock | |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 2,875 | 12,972 (0%) | 0% | 0 | Common Stock | |
| Ariel Hurley | PRINCIPAL ACCOUNTING OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 5,750 | 5,750 | - | - | Stock Option (Right to Buy) | |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 12,500 | 43,374 (0%) | 0% | 0 | Common Stock | |
| Debra Durso-Bumpus | CHIEF PEOPLE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Fouad Namouni | PRESIDENT, R & D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Fouad Namouni | PRESIDENT, R & D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 15,000 | 57,321 (0%) | 0% | 0 | Common Stock | |
| Becker Hewes | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 8,750 | 34,937 (0%) | 0% | 0 | Common Stock | |
| Becker Hewes | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 17,500 | 17,500 | - | - | Stock Option (Right to Buy) | |
| Percy H. Carter | CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 17,500 | 17,500 | - | - | Stock Option (Right to Buy) | |
| Percy H. Carter | CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 8,750 | 30,593 (0%) | 0% | 0 | Common Stock | |
| Kathryn Haviland | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share. | 13 Dec 2021 | 1,000 | 54,948 (0%) | 0% | 36.1 | 36,050 | Common Stock |
| Kathryn Haviland | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2021 | 1,000 | 591 | - | - | Stock Option (Right to Buy) | |
| Kathryn Haviland | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 96.78 per share. | 13 Dec 2021 | 94 | 53,948 (0%) | 0% | 96.8 | 9,097 | Common Stock |
| Kathryn Haviland | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 97.60 per share. | 13 Dec 2021 | 411 | 54,042 (0%) | 0% | 97.6 | 40,114 | Common Stock |
| Kathryn Haviland | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 98.50 per share. | 13 Dec 2021 | 210 | 54,453 (0%) | 0% | 98.5 | 20,685 | Common Stock |
| Kathryn Haviland | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 99.65 per share. | 13 Dec 2021 | 285 | 54,663 (0%) | 0% | 99.6 | 28,400 | Common Stock |
| Tracey McCain | EVP and Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 97.46 per share. | 07 Dec 2021 | 4,328 | 34,113 (0%) | 0% | 97.5 | 421,807 | Common Stock |